University of Leicester

University of Leicester

Name of leader and affiliation
Mike Barer, Professor in microbiology, ULEIC
Dr. Galina Mukamolova, Lecturer in Microbial Physiology

ULEIC is a research intensive university with a well established reputation for microbiology research. Biomedical research in the institution is supported by over £25 million annually and includes substantial EU funding. The ULEIC team have extensive experience in bacterial physiology relevant to MTB through research projects supported by major funders (Research councils and Wellcome Trust). Over the preceding 15 years we have established the significance of mycobacterial Lipd bodies (LBs) and the nature and activity of mycobacterial RPFs. More recently we have demonstrated the presence of LB positive and RPF dependent MTB populations in human sputum samples thereby demonstrating the significance of these phenotypes for human infection. Moreover, both the linkage of these phenotypes to low replication status and antibacterial tolerance makes these in vivo adapted states particularly relevant to the present programme.

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The research leading to these results has received support from the Innovative Medicines Initiative Joint Undertaking under grant agreement n° 115337, resources of which are composed of financial contribution from the European Union's Seventh Framework Programme (FP7/2007-2013) and EFPIA companies’ in kind contribution.

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